Heat-shock protein expression in leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002391" target="_blank" >RIV/00216208:11120/11:00002391 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/11:#0000170
Result on the web
<a href="http://dx.doi.org/10.1007/s13277-010-0088-7" target="_blank" >http://dx.doi.org/10.1007/s13277-010-0088-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13277-010-0088-7" target="_blank" >10.1007/s13277-010-0088-7</a>

Result language
angličtina
Original language name
Heat-shock protein expression in leukemia
Original language description
Heat-shock proteins (Hsps) are thought to play a role in the development of cancer and to modulate tumor response to cytotoxic therapy. In this study, Hsp27, Hsp60, Hsp90alpha, and HspBP1 gene expression was investigated in human leukemia cell lines as well as in leukemia cells derived from patients with the onset of the disease. Hsp70 membrane expression and expression of Hsp27, Hsp60, Hsp70, Hsp90alpha, and HspBP1 genes were also tested in samples from leukemia patients. Relative Hsps gene expressionwas examined in human leukemia cell lines and also in patients, using real-time quantitative reverse-transcriptase polymerase chain reaction (RT-PCR). Hsp70 cell surface expression was studied in patients with leukemia onset using flow cytometry. All tested cell lines showed significantly increased expression of Hsp60, Hsp90alpha, and HspBP1 genes compared with a cohort of healthy controls; additionally there was increased Hsp27 expression except for Jurkat and CCRF cells. Significantly
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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