Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003200" target="_blank" >RIV/00216208:11120/11:00003200 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/11:7109
Result on the web
<a href="http://dx.doi.org/10.3109/03009742.2011.552522" target="_blank" >http://dx.doi.org/10.3109/03009742.2011.552522</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/03009742.2011.552522" target="_blank" >10.3109/03009742.2011.552522</a>
Alternative languages
Result language
angličtina
Original language name
Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls
Original language description
Heat shock proteins (Hsps) have been repeatedly implicated in the pathogenesis of rheumatoid arthritis (RA). The objective of this work was to study Hsps mRNA and protein levels to determine if they can be used to differentitate between rheumatiod arthritis (RA), osteoarthrosis (OA) and healthy controls. Hsp gene expression profiles differ significantly between inflammatory (RA) and non-inflammatory (OA) joint diseases showing significantly increased Hsp27 and Hsp90 mRNA levels in RA synovial tissues. Up-regulated Hsp60 and Hsp90 together with down-regulated Hsp70 and elevated HspBP1/Hsp70 mRNA ratios can be used to differentiate between RA patients and healthy individuals through analysis of peripheral blood samples. Despite increased HspBP1 levels inRA sera, Hsp70 levels and the HspBP1/Hsp70 protein ratio remained identical in the RA patients and healthy individuals, which may contribute to the inhibition of Hsp70 anti-apoptotic activity. Hsp gene expression analysis can be implemen
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scandinavian Journal of Rheumatology
ISSN
0300-9742
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
5
Country of publishing house
NO - NORWAY
Number of pages
4
Pages from-to
354-357
UT code for WoS article
000295476300005
EID of the result in the Scopus database
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