Anxiety-like behaviour in the elevated-plus maze tests and enhanced IL-1beta, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002662" target="_blank" >RIV/00216208:11120/11:00002662 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.neulet.2010.10.032" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2010.10.032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2010.10.032" target="_blank" >10.1016/j.neulet.2010.10.032</a>

Result language

angličtina

Original language name

Anxiety-like behaviour in the elevated-plus maze tests and enhanced IL-1beta, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats

Original language description

We studied anxiety-like behavior in the elevated plus-maze (EPM) tests in male Lewis rats on days 2 and 4 of adjuvant arthritis (AA). In plasma we analyzed C-reactive protein (CRP), albumin, ACTH, corticosterone, in the hippocampus the mRNA expression ofinterleukin-1? (IL-1?), interleukin-6 (IL-6), corticotrophin releasing factor (CRH), NADPH oxidases NOX1 and NOX2, and inducible NO-synthase (iNOS). EPM tests showed a higher anxiety index in AA rats on days 2 and 4 and reduction of total entries. On days 2 and 4 we found reduced plasma albumin, enhanced CRP, ACTH and corticosterone, and in the hippocampus enhanced mRNA for NOX1 and IL-1? in AA rats, on day 4 we found enhanced mRNAs for iNOS and IL-6, and reduced mRNA for CRH. The mRNA for NOX2 did notchange on any experimental day. These results suggest enhanced anxiety, as well as locomotor impairment during the early phase of AA that correlate with enhanced mRNA expressions of parameters of oxidative stress NOX1, iNOS, and inflamma

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Volume of the periodical

487

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

250-254

UT code for WoS article

000286793100026

EID of the result in the Scopus database

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