Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003172" target="_blank" >RIV/00216208:11120/11:00003172 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbr.2011.05.021" target="_blank" >http://dx.doi.org/10.1016/j.bbr.2011.05.021</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbr.2011.05.021" target="_blank" >10.1016/j.bbr.2011.05.021</a>

Result language
angličtina
Original language name
Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats?
Original language description
Methamphetamine (MA) is one of the most frequently used illicit drugs worldwide and also one of the most common drugs abused by pregnant women. Repeated administration of psychostimulants induces behavioral sensitization in response to treatment of the same or related drugs in rodents. The effect of prenatal MA exposure on sensitivity to drugs in adulthood is not yet fully determined. Because our most recent studies demonstrated that prenatal MA (5 mg/kg) exposure makes adult rats more sensitive to acute injection of the same drug, we were interested whether the increased sensitivity corresponds with the increased drug-seeking behavior. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult malerats tested in the conditioned place preference (CPP). The following psychostimulant drugs were used as a challenge in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg) and cocaine (10 mg/kg). All psychostimulant drugs induced increased dru
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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