Ornithine decarboxylase G316A genotype and colorectal cancer risk

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003237" target="_blank" >RIV/00216208:11120/11:00003237 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/11:00347503 RIV/75010330:_____/11:00009218

Result on the web

<a href="http://dx.doi.org/10.1111/j.1463-1318.2010.02300.x" target="_blank" >http://dx.doi.org/10.1111/j.1463-1318.2010.02300.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1463-1318.2010.02300.x" target="_blank" >10.1111/j.1463-1318.2010.02300.x</a>

Result language

angličtina

Original language name

Ornithine decarboxylase G316A genotype and colorectal cancer risk

Original language description

Ornithine decarboxylase (ODC) is a modifier of adenomatous polyposis coli-dependent tumourigenesis. The G316 > A polymorphism in intron 1 of the ODC gene lies between two myc-binding domains and alters the expression of the gene to affect polyamine metabolism. This variant may be associated with recurrence of colorectal adenoma. We examined whether this variant also modified the susceptibility to sporadic colorectal cancer (CRC). The G316 > A variant was analysed in a large (n = 754) CRC case-controlledseries of hospital patient volunteers (n = 627) in the Czech Republic, and the relationship with cancer risk was estimated by conditional logistic regression. After adjusting for age and sex, G316 > A was associated with no decrease in CRC risk for either heterozygotes [odds ratio 0.98, 95% confidence interval (CI) 0.77-1.23] or rare allele homozygotes (odds ratio 0.92, 95% CI 0.6-1.37). The G316 > A functional variant in the ODC gene is unlikely to make much impact on reducing CRC risk

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Colorectal Disease

ISSN

1462-8910

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

860-864

UT code for WoS article

000292844200020

EID of the result in the Scopus database

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