Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00379743" target="_blank" >RIV/68378041:_____/12:00379743 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/cncr.27435" target="_blank" >http://dx.doi.org/10.1002/cncr.27435</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cncr.27435" target="_blank" >10.1002/cncr.27435</a>
Alternative languages
Result language
angličtina
Original language name
Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome
Original language description
We have found statistically significant associations between the risk of CRC and the variant alleles of KIAA0182 (rs709805) (odds ratio (OR):1.57; 95% confidence interval (CI) 1.06?2.78, for the variant homozygotes) and NUP210 genes (rs354476) (OR = 1.36; 95% CI = 1.02-1.82, for the variant homozygotes). Our results support the hypothesis and highlight the importance of SNPs within miRNA-dependent regulatory regions. Further studies on the role exerted by NUP210 and KIAA0182 in colorectal carcinogenesisare required.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer
ISSN
1934-662X
e-ISSN
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Volume of the periodical
118
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
4670-4680
UT code for WoS article
000308931900007
EID of the result in the Scopus database
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