The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003379" target="_blank" >RIV/00216208:11120/11:00003379 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/11:00370654 RIV/68407700:21460/11:00190798 RIV/00064203:_____/11:7110
Result on the web
<a href="http://dx.doi.org/10.1186/1748-717X-6-87" target="_blank" >http://dx.doi.org/10.1186/1748-717X-6-87</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1748-717X-6-87" target="_blank" >10.1186/1748-717X-6-87</a>

Result language
angličtina
Original language name
The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques
Original language description
Our research compared whole pelvic (WP) and prostate-only (PO) 3-dimensional conformal radiotherapy (3DCRT) techniques in terms of the incidence and evolution of acute and late toxicity of the rectum and urinary bladder, and identified the PTV-parametersinfluencing these damages and changes in antitumor immune response. We analyzed 197 prostate cancer patients undergoing 3DCRT for gastrointestinal (GI) and genitourinary (GU) toxicities, and conducted a pilot immunological study including flow cytometryand an NK cell cytotoxicity assay. Acute and late toxicities were recorded according to the RTOG and the LENT-SOMA scales, respectively. Univariate and multivariate analyses were conducted for factors associated with toxicity. In the WP group, an increase of acute rectal toxicity was observed. A higher incidence of late GI/GU toxicity appeared in the PO group. Only 18 patients (WP-7.76% and PO-11.11%) suffered severe late GI toxicity, and 26 patients (WP-11.21% and PO-16.05%) severe lat
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—

Project
<a href="/en/project/IAA500200620" target="_blank" >IAA500200620: Dynamics of CD161 antigen expression on cytotoxic cells and involved signaling pathways upon saccharide ligand interaction</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)