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Image-guided radiation therapy produces lower acute and chronic gastrointestinal and genitourinary toxicity in prostate cancer patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43921808" target="_blank" >RIV/00216208:11120/21:43921808 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/21:00557094 RIV/00216208:11110/21:10429425 RIV/61989592:15110/21:73608595

  • Result on the web

    <a href="https://jbuon.com/archive/26-3-940.pdf" target="_blank" >https://jbuon.com/archive/26-3-940.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Image-guided radiation therapy produces lower acute and chronic gastrointestinal and genitourinary toxicity in prostate cancer patients

  • Original language description

    Purpose: This paper compares individual radiation therapy techniques used for prostate cancer and their benefits in clinical practice. Methods: We retrospectively analyzed 921 patients with localized prostate tumors treated between 1997 and 2012. We divided the patients into four groups according to the selected treatment technique (conformal radiation therapy [3DCRT], intensity-modulated radiation therapy [IMRT], image-guided radiation therapy [IGRT], and volumetric-modulated arc therapy [VMAT]) and evaluated the incidence of acute and chronic gastrointestinal (GI) and genitourinary (GU) toxicity. Results: The incidence of grade 2 or greater acute GU and GI toxicity was significantly higher among techniques other than IGRT (p&lt;0.001). We found the same results in the case of grade 3 or greater acute GU toxicity (p&lt;0.001). Grade 3 or higher acute GI toxicity occurred only in one patient treated by 3DCRT. Cumulative late GI toxicity of grade 2 or higher and grade 3 or higher was recorded over 3 years significantly more frequently among non-IGRT techniques as compared to IGRT (p&lt;0.001). As regards GU toxicity, we found significantly higher incidence only for grade 2 or higher (p&lt;0.001), not for grade 3 or higher. No occurrence of grade 4 toxicity was recorded. The greatest incidence of patients without acute and chronic GI/GU toxicity was recorded in connection with VMAT. Conclusions: IGRT demonstrated a pronounced reduction in acute and chronic GU and GI toxicity as compared to non-IGRT techniques in the treatment of localized prostate cancer.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of B.U.O.N.

  • ISSN

    1107-0625

  • e-ISSN

  • Volume of the periodical

    26

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    GR - GREECE

  • Number of pages

    9

  • Pages from-to

    940-948

  • UT code for WoS article

    000668891800005

  • EID of the result in the Scopus database

    2-s2.0-85109739632