High frequency of complex TP53 mutations in CNS metastases from breast cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A00003514" target="_blank" >RIV/00216208:11120/12:00003514 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/12:00003514
Result on the web
<a href="http://dx.doi.org/10.1038/bjc.2011.464" target="_blank" >http://dx.doi.org/10.1038/bjc.2011.464</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/bjc.2011.464" target="_blank" >10.1038/bjc.2011.464</a>

Result language
angličtina
Original language name
High frequency of complex TP53 mutations in CNS metastases from breast cancer
Original language description
Brain metastasis from breast cancer is usually associated with a poor prognosis and early death. Alteration of p53 may contribute to malignant progression by abrogation of apoptosis induced by oncogene activation and by acquisition of gain-of-function properties, which promote tumour aggression. Mutation in TP53 occurs at high frequency in carcinomas of the lung and gastro-intestinal tract, but is much less frequent, at 25%, in primary breast cancer. The frequency of TP53 alteration in the central nervous system (CNS) metastatic breast cancer is not known. Methods: In all, 23 cases of histologically confirmed CNS metastatic breast cancer were identified and the coding sequence of TP53 determined. TP53 was also sequenced in two control series of primarybreast carcinomas from independent clinical centres. Results: We demonstrate a strikingly high frequency of TP53 mutation in the CNS metastatic lesions with an over-representation of complex mutations (non-sense/deletions/insertions). Co
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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