Iron overload and HFE gene mutations in Czech patients with chronic liver diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A00003586" target="_blank" >RIV/00216208:11120/12:00003586 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/12:#0000057
Result on the web
<a href="http://dx.doi.org/10.3233/DMA-2012-0861" target="_blank" >http://dx.doi.org/10.3233/DMA-2012-0861</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2012/790464" target="_blank" >10.1155/2012/790464</a>
Alternative languages
Result language
angličtina
Original language name
Iron overload and HFE gene mutations in Czech patients with chronic liver diseases
Original language description
The aim of the study was to identify the prevalence of HFE gene mutations in Czech patients with chronic liver diseases and the influence of the mutations on iron status. The presence of HFE gene mutations (C282Y, H63D, and S65C) analyzed by the PCR-RFLPmethod, presence of cirrhosis, and serum iron indices were compared among 454 patients with different chronic liver diseases (51 with chronic hepatitis B, 122 with chronic hepatitis C, 218 with alcoholic liver disease, and 63 patients with hemochromatosis). Chronic liver diseases patients other than hemochromatics did not have an increased frequency of HFE gene mutations compared to controls. Although 33.3% of patients with hepatitis B, 43% of patients with hepatitis C, and 73.2% of patients with alcoholic liver disease had elevated transferrin saturation or serum ferritin levels, the presence of HFE gene mutations was not significantly associated with iron overload in these patients. Additionally, patients with cirrhosis did not have
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9164" target="_blank" >NR9164: Clinical and functional correlates of hypertrophic cardiomyopathy in Czech population</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Disease Markers
ISSN
0278-0240
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
65-72
UT code for WoS article
000300107400007
EID of the result in the Scopus database
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