Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A00003851" target="_blank" >RIV/00216208:11120/12:00003851 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/12:00003851

Result on the web

<a href="http://dx.doi.org/10.1038/nature10730" target="_blank" >http://dx.doi.org/10.1038/nature10730</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nature10730" target="_blank" >10.1038/nature10730</a>

Result language

angličtina

Original language name

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Original language description

Oestrogen receptor-? (ER) is the defining and driving transcription factor in the majority of breast cancers and its target genes dictate cell growth and endocrine response, yet genomic understanding of ER function has been restricted to model systems1,2, 3. Here we map genome-wide ER-binding events, by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq), in primary breast cancers from patients with different clinical outcomes and in distant ER-positive metastases. We find that drug-resistant cancers still recruit ER to the chromatin, but that ER binding is a dynamic process, with the acquisition of unique ER-binding regions in tumours from patients that are likely to relapse. The acquired ER regulatory regions associated with poor clinical outcome observed in primary tumours reveal gene signatures that predict clinical outcome in ER-positive disease exclusively. We find that the differential ER-binding programme observed in tumours from patients with poor

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature

ISSN

0028-0836

e-ISSN

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Volume of the periodical

481

Issue of the periodical within the volume

7381

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

389-393

UT code for WoS article

000299210600048

EID of the result in the Scopus database

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