Expression of oxysterol pathway genes in oestrogen-positive breast carcinomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F17%3A00011770" target="_blank" >RIV/75010330:_____/17:00011770 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/17:43913195 RIV/00216208:11130/17:10337709 RIV/00216208:11140/17:10337709 RIV/61989592:15110/17:73583821 and 2 more
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/cen.13337/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/cen.13337/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cen.13337" target="_blank" >10.1111/cen.13337</a>
Alternative languages
Result language
angličtina
Original language name
Expression of oxysterol pathway genes in oestrogen-positive breast carcinomas
Original language description
Objective: This study investigated whether gene expression levels of key modulators of the oxysterol signalling pathway modify the prognosis of patients with oestrogen receptor-positive (ER+) breast carcinomas via interaction with endocrine therapy. Context: The prognosis of patients with ER+ breast carcinoma depends on several factors. Previous studies have suggested that some oxygenated forms of cholesterol (oxysterols) bind to oestrogen receptor and anti-oestrogen binding site which may deregulate cholesterol homoeostasis and influence effect of therapy. Design: The expression levels of 70 oxysterol pathway genes were evaluated in a test set of breast carcinomas differing in ER expression. The genes differentially expressed in ER+ tumours were assessed in a comprehensive set of ER+ tumours to evaluate their clinical significance. Patients: A total of 193 primary patients with breast carcinoma were included. Measurements: The transcript levels were determined by quantitative real-time polymerase chain reaction. Results: The expression levels of 23 genes were found to be specifically dysregulated in ER+ tumours compared to ER-tumours of the test set. The expression levels of ABCG2, CYP7B1, CYP24A1, CYP39A1 and CH25H genes were found to be strongly associated with disease stage; however, none of the gene expression levels were associated with disease-free survival in patients treated with endocrine therapy. Conclusions: The expression of a number of oxysterol pathway genes is significantly modulated by ER expression and associated with the clinical stage of patients. However, the expression of oxysterol pathway genes was not found to modify the prognosis of ER+ patients with breast carcinoma treated with endocrine therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Endocrinology
ISSN
0300-0664
e-ISSN
1365-2265
Volume of the periodical
86
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
852-861
UT code for WoS article
000403714100013
EID of the result in the Scopus database
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