Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43919438" target="_blank" >RIV/00216208:11120/20:43919438 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/20:10401696 RIV/00216208:11140/20:10401696 RIV/00064203:_____/20:10401696 RIV/75010330:_____/20:00012988
Result on the web
<a href="https://doi.org/10.1016/j.jsbmb.2019.105566" target="_blank" >https://doi.org/10.1016/j.jsbmb.2019.105566</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jsbmb.2019.105566" target="_blank" >10.1016/j.jsbmb.2019.105566</a>
Alternative languages
Result language
angličtina
Original language name
Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data
Original language description
Oxygenated metabolites of cholesterol (oxysterols) have been previously demonstrated to contribute to progression of various cancers and to modulate resistance to breast cancer endocrine therapy in vitro. We measured prognostic roles of circulating levels of seven major oxysterols in the progression of luminal subtype breast carcinoma. Liquid chromatography coupled with tandem mass spectrometry was used for determination of levels of non-esterified 25-hydroxycholesterol, 27-hydroxycholesterol, 7α-hydroxycholesterol, 7-ketocholesterol, cholesterol-5α,6α-epoxide, cholesterol-5β,6β-epoxide, and cholestane-3β,5α,6β-triol in plasma samples collected from patients (n = 58) before surgical removal of tumors. Oxysterol levels were then associated with clinical data of patients. All oxysterols except cholesterol-5α,6α-epoxide were detected in patient plasma samples. Circulating levels of 7α-hydroxycholesterol and 27-hydroxycholesterol were significantly lower in patients with small tumors (pT1) and cholesterol-5β,6β-epoxide and cholestane-3β,5α,6β-triol were lower in patients with stage IA disease compared to larger tumors or more advanced stages. Patients with higher than median cholestane-3β,5α,6β-triol levels had significantly worse disease-free survival than patients with lower levels (p = 0.037 for all patients and p = 0.015 for subgroup treated only with tamoxifen). In conclusion, this study shows, for the first time, that circulating levels of oxysterols, especially cholestane-3β,5α,6β-triol, may have prognostic roles in patients with luminal subtype breast cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Steroid Biochemistry & Molecular Biology
ISSN
0960-0760
e-ISSN
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Volume of the periodical
197
Issue of the periodical within the volume
March
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
"Article 105566"
UT code for WoS article
000518664800015
EID of the result in the Scopus database
2-s2.0-85076670295