Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor kappa B (NF-kappa B) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00080960" target="_blank" >RIV/00216224:14310/15:00080960 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1074/mcp.M114.041335" target="_blank" >http://dx.doi.org/10.1074/mcp.M114.041335</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1074/mcp.M114.041335" target="_blank" >10.1074/mcp.M114.041335</a>

Result language

angličtina

Original language name

Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor kappa B (NF-kappa B) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer

Original language description

Current prognostic factors are insufficient for precise risk-discrimination in breast cancer patients with low grade breast tumors, which, in disagreement with theoretical prognosis, occasionally form early lymph node metastasis. To identify markers forthis group of patients, we employed iTRAQ-2DLC-MS/MS proteomics to 24 lymph node positive and 24 lymph node negative grade 1 luminal A primary breast tumors. Another group of 48 high-grade tumors (luminal B, triple negative, Her-2 subtypes) was also analyzed to investigate marker specificity for grade 1 luminal A tumors. From the total of 4405 proteins identified (FDR&lt;5%), the top 65 differentially expressed together with 30 previously identified and control markers were analyzed also at transcript level.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA14-19250S" target="_blank" >GA14-19250S: A novel panel of proteins associated with lymph node status in low-grade breast cancer: Clinical verification and role in tumor cell invasiveness</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MOLECULAR &amp; CELLULAR PROTEOMICS

ISSN

1535-9476

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

1814-1830

UT code for WoS article

000357434400007

EID of the result in the Scopus database

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