Combined proteomics and transcriptomics identifies carboxypeptidase B1 and nuclear Factor ?B (NF-?B) associated proteins as putative biomarkers of metastasis in low grade breast cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000614" target="_blank" >RIV/00209805:_____/15:#0000614 - isvavai.cz</a>
Result on the web
<a href="http://www.mcponline.org/cgi/pmidlookup?view=long&pmid=25903579" target="_blank" >http://www.mcponline.org/cgi/pmidlookup?view=long&pmid=25903579</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1074/mcp.M114.041335" target="_blank" >10.1074/mcp.M114.041335</a>

Result language
angličtina
Original language name
Combined proteomics and transcriptomics identifies carboxypeptidase B1 and nuclear Factor ?B (NF-?B) associated proteins as putative biomarkers of metastasis in low grade breast cancer
Original language description
Current prognostic factors are insufficient for precise risk-discrimination in breast cancer patients with low grade breast tumors, which, in disagreement with theoretical prognosis, occasionally form early lymph node metastasis. To identify markers forthis group of patients, we employed iTRAQ-2DLC-MS/MS proteomics to 24 lymph node positive and 24 lymph node negative grade 1 luminal A primary breast tumorsFrom the total of 4405 proteins identified (FDR<5%), the top 65 differentially expressed togetherwith 30 previously identified and control markers were analyzed also at transcript level. Increased levels of carboxypeptidase B1 (CPB1), PDZ and LIM domain protein 2 (PDLIM2), and ring finger protein 25 (RNF25) were associated specifically with lymph node positive grade 1 tumors, whereas stathmin 1 (STMN1) and thymosin beta 10 (TMSB10) associated with aggressive tumor phenotype also in high grade tumors at both protein and transcript level. For CPB1, these differences were also observed
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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