Testicular Sperm Aneuploidy in Nonobstructive Azoospermic Patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43902226" target="_blank" >RIV/00216208:11120/12:43902226 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/12:#0000890 RIV/00064173:_____/12:43902226
Result on the web
<a href="http://dx.doi.org/10.1093/humrep/des115" target="_blank" >http://dx.doi.org/10.1093/humrep/des115</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/humrep/des115" target="_blank" >10.1093/humrep/des115</a>

Result language
angličtina
Original language name
Testicular Sperm Aneuploidy in Nonobstructive Azoospermic Patients
Original language description
BACKGROUND: Nonobstructive azoospermic (NOA) men can father children after testicular sperm extraction (TESE). They were shown to be at risk of producing chromosomally abnormal spermatozoa, but the number of sperm analysed per patient is usually very low. METHODS: Multicolor fluorescence in situ hybridization was used for detection of chromosome 13, 15, 16, 18, 21, 22, X and Y disomy and diploidy in sperm obtained from NOA men (n=17) and control donors (n=10). At least 500 testicular sperm were scored in each patient to increase the predictability rate of our study. RESULTS: The mean frequency of overall disomy (2.32%) and diploidy (0.80%) found in 13,689 testicular spermatozoa of NOA patients was significantly higher than in the ejaculated sperm of normospermic control donors (0.62% of disomy and 0.29% of diploidy). A highly significant increase in frequencies of chromosome 15, Y and overall disomy (P<0.001), and a significant increase in disomy of chromosome 13 (P=0.002), 16 (P=0.031
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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