Individual variation in the frequency of sperm aneuploidy in humans

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F05%3A06000026" target="_blank" >RIV/00027162:_____/05:06000026 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Individual variation in the frequency of sperm aneuploidy in humans

Original language description

To examine interindividual differences in sperm chromosome aneuploidy, repeated semen specimens were obtained from a group of ten healthy men, aged 20-21 at the start of the study, and analyzed by FISH to determine the frequencies of sperm aneuploidy forchromosomes X, Y, 8, 18 and 21 and of diploidy. Men were sampled three times over a 5-year period. Statistical analysis examining the stability of sperm aneuploidy over time by type and chromosome identified two men who consistently exhibited elevatedfrequencies of sperm aneuploidy. Overall, disomy frequencies were lower for chromosome X, 8 and 18 than for chromosomes 21 or Y and for XY aneuploidy. The frequency of chromosome Y disomy did not differ from XY sperm frequency. Frequencies of spermaneuploidy were similar between the first sampling period and the second, two years later. However, the frequency of some types of aneuploidy increased significantly between the first sampling period and the last, five years later.

Czech name

Individuální variace ve frekvenci aneuploidií v lidských spermiích

Czech description

Spermie 10 mladých mužů byly vyšetřeny třikrát v průběhu pěti let na frekvenci aneuploidií chromozomů pomocí FISH. Byla popsána vysoká interindividuální variabilita ve frekvenci aneuploidií chromozomů ve spermiích, které mohou u některých jedinců vyvolatzvýšené riziko narození vývojové vady a embryonální mortality. U některých typů aneuploidií došlo k zvýšení frekvence mezi prvním a posledním vyšetření, tedy s věkem.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytogenetic and Genome Research

ISSN

1424-8581

e-ISSN

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Volume of the periodical

111

Issue of the periodical within the volume

3-4

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

229-236

UT code for WoS article

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EID of the result in the Scopus database

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