TFAP2B influences the effect of dietary fat on weight loss under energy restriction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906473" target="_blank" >RIV/00216208:11120/12:43906473 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/12:#0000234
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0043212" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0043212</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0043212" target="_blank" >10.1371/journal.pone.0043212</a>
Alternative languages
Result language
angličtina
Original language name
TFAP2B influences the effect of dietary fat on weight loss under energy restriction
Original language description
Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction. Randomized controlled trial of 771 obese adults. (Registration: ISRCTN25867281.) One SNP was selected for replication in another weight loss intervention study of 934 obese adults. The original trial was a 10-week 600 kcal/d energy-deficient diet with energy percentage from fat (fat%) in range of 20-25 or 40-45. The replication study used an 8-weeks diet of 880 kcal/d and 20 fat%; change in fat% intake was used for estimation of interaction effects. The main outcomes were intervention weight loss and waist reduction. In the trial, mean change in fat% intake was -12/+4 in the low/high-fat groups. In the replication study, it was -23/-12 among those reducing fat% more/less than the median. TFAP2B-rs987237 genotype AA was associated with 1.0 kg (
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"Art. Nr. e43212; s.1"-10
UT code for WoS article
000308044800023
EID of the result in the Scopus database
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