Structure and pathology of tau protein in Alzheimer disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906685" target="_blank" >RIV/00216208:11120/12:43906685 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/12:43913799
Result on the web
<a href="http://dx.doi.org/10.1155/2012/731526" target="_blank" >http://dx.doi.org/10.1155/2012/731526</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2012/731526" target="_blank" >10.1155/2012/731526</a>
Alternative languages
Result language
angličtina
Original language name
Structure and pathology of tau protein in Alzheimer disease
Original language description
Alzheimer's disease (AD) is the most common type of dementia. In connection with the global trend of prolonging human life and the increasing number of elderly in the population, the AD becomes one of the most serious health and socioeconomic problems ofthe present. Tau protein promotes assembly and stabilizes microtubules, which contributes to the proper function of neuron. Alterations in the amount or the structure of tau protein can affect its role as a stabilizer of microtubules as well as some ofthe processes in which it is implicated. The molecular mechanisms governing tau aggregation are mainly represented by several posttranslational modifications that alter its structure and conformational state. Hence, abnormal phosphorylation and truncation of tau protein have gained attention as key mechanisms that become tau protein in a pathological entity. Evidences about the clinicopathological significance of phosphorylated and truncated tau have been documented during the progressio
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP304%2F12%2FG069" target="_blank" >GBP304/12/G069: Project of excellence in the field of neuroscience</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Alzheimer's Disease
ISSN
2090-0252
e-ISSN
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Volume of the periodical
2012
Issue of the periodical within the volume
Art.ID 731526, Online 29 May
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1-13
UT code for WoS article
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EID of the result in the Scopus database
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