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Structure and pathology of tau protein in Alzheimer disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906685" target="_blank" >RIV/00216208:11120/12:43906685 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023752:_____/12:43913799

  • Result on the web

    <a href="http://dx.doi.org/10.1155/2012/731526" target="_blank" >http://dx.doi.org/10.1155/2012/731526</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2012/731526" target="_blank" >10.1155/2012/731526</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structure and pathology of tau protein in Alzheimer disease

  • Original language description

    Alzheimer's disease (AD) is the most common type of dementia. In connection with the global trend of prolonging human life and the increasing number of elderly in the population, the AD becomes one of the most serious health and socioeconomic problems ofthe present. Tau protein promotes assembly and stabilizes microtubules, which contributes to the proper function of neuron. Alterations in the amount or the structure of tau protein can affect its role as a stabilizer of microtubules as well as some ofthe processes in which it is implicated. The molecular mechanisms governing tau aggregation are mainly represented by several posttranslational modifications that alter its structure and conformational state. Hence, abnormal phosphorylation and truncation of tau protein have gained attention as key mechanisms that become tau protein in a pathological entity. Evidences about the clinicopathological significance of phosphorylated and truncated tau have been documented during the progressio

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GBP304%2F12%2FG069" target="_blank" >GBP304/12/G069: Project of excellence in the field of neuroscience</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Alzheimer's Disease

  • ISSN

    2090-0252

  • e-ISSN

  • Volume of the periodical

    2012

  • Issue of the periodical within the volume

    Art.ID 731526, Online 29 May

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    1-13

  • UT code for WoS article

  • EID of the result in the Scopus database