Innate-like behavior of human invariant natural killer T cells during herpes simplex virus infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906840" target="_blank" >RIV/00216208:11120/12:43906840 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.cellimm.2012.06.004" target="_blank" >http://dx.doi.org/10.1016/j.cellimm.2012.06.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cellimm.2012.06.004" target="_blank" >10.1016/j.cellimm.2012.06.004</a>

Result language
angličtina
Original language name
Innate-like behavior of human invariant natural killer T cells during herpes simplex virus infection
Original language description
Invariant natural killer T (iNKT) cells, CD1d restricted T cells, are involved in the immune responses against various infection agents. Here we describe their behavior during reactivation of human herpes simplex virus (HSV). iNKT cells exhibit only discrete changes, which however, reached statistically significant level due to the relatively large patient group. Higher percentage of iNKT cells express NKG2D. iNKT cells down-regulate NKG2A in a subset of patients. Finally, iNKT cells enhance their capacity to produce TNF-alpha. Our data suggests that iNKT cells are involved in the immune response against HSV and contribute mainly to its early, innate phase.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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