NT5E CpG island methylation is a favourable breast cancer biomarker

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906998" target="_blank" >RIV/00216208:11120/12:43906998 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/12:43906998

Result on the web

<a href="http://dx.doi.org/10.1038/bjc.2012.212" target="_blank" >http://dx.doi.org/10.1038/bjc.2012.212</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/bjc.2012.212" target="_blank" >10.1038/bjc.2012.212</a>

Result language

angličtina

Original language name

NT5E CpG island methylation is a favourable breast cancer biomarker

Original language description

Relapse risk assessment and individual treatment recommendations remain suboptimal for breast cancer patients. In the light of existing preclinical and clinical data, we studied NT5E (5'-nucleotidase, ecto) expression and NT5E CpG island methylation in breast cancer. METHODS: We used RT-PCR, qPCR, methylation-specific PCR and pyrosequencing to analyse NT5E in breast carcinoma cell lines and primary and breast carcinomas. RESULTS: NT5E CpG island methylation was inversely associated with NT5E expressionin breast carcinoma cell lines. In clinical series, patients whose primary tumours had NT5E CpG island methylation were less likely to develop metastasis (P = 0.003, OR = 0.34, 95% CI: 0.17-0.69). In 3/4 paired samples, NT5E was methylated in primary tumours and demethylated in CNS metastases. Patients progressing to non-visceral as compared with visceral metastases were more likely to have NT5E CpG island methylation in primary tumours (P = 0.01, OR = 11.8). Patients with tumours lackin

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Cancer

ISSN

0007-0920

e-ISSN

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Volume of the periodical

107

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

75-83

UT code for WoS article

000305888400012

EID of the result in the Scopus database

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