Site-specific CpG methylation in the CCAAT/enhancer binding protein delta (CEBP delta) CpG island in breast cancer is associated with metastatic relapse
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906430" target="_blank" >RIV/00216208:11120/12:43906430 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/12:43906430
Result on the web
<a href="http://dx.doi.org/10.1038/bjc.2012.308" target="_blank" >http://dx.doi.org/10.1038/bjc.2012.308</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/bjc.2012.308" target="_blank" >10.1038/bjc.2012.308</a>
Alternative languages
Result language
angličtina
Original language name
Site-specific CpG methylation in the CCAAT/enhancer binding protein delta (CEBP delta) CpG island in breast cancer is associated with metastatic relapse
Original language description
The CCAAT/enhancer binding protein delta (CEBP delta) is a member of a highly conserved family of basic region leucine zipper transcription factors. It has properties consistent with a tumour suppressor; however, other data suggest that CEBP delta may beinvolved in the metastatic process. METHODS: We analysed the expression of CEBP delta and the methylation status of the CpG island in human breast cancer cell lines, in 107 archival cases of primary breast cancer and in two series of metastatic breast cancers using qPCR and pyrosequencing. RESULTS: Expression of CEBP delta is downregulated in primary breast cancer by site-specific methylation in the CEBP delta CpG island. Expression is also downregulated in 50% of cases during progression from primarycarcinoma to metastatic lesions. The CEBP delta CpG island is methylated in 81% metastatic breast cancer lesions, while methylation in the CEBP delta CpG island in primary cancers is associated with increased risk of relapse and metastasi
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Cancer
ISSN
0007-0920
e-ISSN
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Volume of the periodical
107
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
732-738
UT code for WoS article
000307770300022
EID of the result in the Scopus database
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