Immunogenicity and safety of pandemic H1N1 2009 influenza vaccine for HIV-1 patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43907065" target="_blank" >RIV/00216208:11120/12:43907065 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4149/av_2012_04_349" target="_blank" >http://dx.doi.org/10.4149/av_2012_04_349</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/av_2012_04_349" target="_blank" >10.4149/av_2012_04_349</a>

Result language

angličtina

Original language name

Immunogenicity and safety of pandemic H1N1 2009 influenza vaccine for HIV-1 patients

Original language description

The advent of the 2009 H1N1 pandemic influenza has raised concerns about the immunogenicity and safety of vaccines against the new virus, especially in immunocompromised individuals. In our study we evaluated the immunogenicity and safety of pandemic influenza vaccine in 34 HIV-1 infected patients. For immunization was we used a single dose of adjuvanted inactivated split-virion pandemic H1N1 influenza vaccine containing 3.75 ug of hemagglutinin (A/California/7/2009) and adjuvant AS03. Two serum sampleswere collected from each patient - first on day 0, just before vaccination and the other on day 28, after vaccination. Antibody production was tested by hemagglutinin inhibition assay according to the World Health Organization methodology. The mean baseline CD4+ T lymphocyte count was 511/ul (range 90-1151). After vaccination, protective titers >1:40 were found in 24 (70.5%) vaccines, and at least a fourfold increase in antibody titers was detected in 27 vaccines (79.4%). Seroconversion

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Virologica

ISSN

0001-723X

e-ISSN

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Volume of the periodical

56

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

3

Pages from-to

349-351

UT code for WoS article

000313403400011

EID of the result in the Scopus database

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