Mechanism of paracetamol-induced hypotension in critically ill patients: A prospective observational cross-over study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43896918" target="_blank" >RIV/00216208:11120/13:43896918 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.aucc.2012.02.002" target="_blank" >http://dx.doi.org/10.1016/j.aucc.2012.02.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aucc.2012.02.002" target="_blank" >10.1016/j.aucc.2012.02.002</a>

Result language

angličtina

Original language name

Mechanism of paracetamol-induced hypotension in critically ill patients: A prospective observational cross-over study

Original language description

Objective: To elucidate the mechanism of hypotension following intravenous administration of paracetamol (acetaminophen) to patients on the Intensive Care Unit. Ventilated critically ill patients monitored by PiCCO and administered intravenous paracetamol at the same time were eligible for the study. We recorded haemodynamic indices, as well as core and peripheral temperatures, continuously for 3 h after the dose of paracetamol. Ranitidine was then used as a control drug known not to influence haemodynamics. Results: We included 6 subjects, and recorded 48 cycles of observations after administration of paracetamol, and 35 cycles after administration of the control drug. Haemodynamic parameters were not different at the baseline and administration of control drug did not result in any change in haemodynamics. After intravenous paracetamol, mean arterial pressure (MAP) dropped by 7% (p < 0.001) with a nadir at the 19th minute. In 22 measurement cycles (45%) we noted >15% reduction in MAP

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Australian Critical Care

ISSN

1036-7314

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

8

Pages from-to

136-141

UT code for WoS article

000324821600008

EID of the result in the Scopus database

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