The relevance of monitoring of antibodies against the Polycyclic aromatic hydrocarbon (PAH) and PAH-DNA adducts in serum in relation to lung cancer and chronic obstructive pulmonary disease (COPD)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906911" target="_blank" >RIV/00216208:11120/13:43906911 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00395363 RIV/00064211:_____/13:#0000264
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2013_024" target="_blank" >http://dx.doi.org/10.4149/neo_2013_024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2013_024" target="_blank" >10.4149/neo_2013_024</a>

Result language
angličtina
Original language name
The relevance of monitoring of antibodies against the Polycyclic aromatic hydrocarbon (PAH) and PAH-DNA adducts in serum in relation to lung cancer and chronic obstructive pulmonary disease (COPD)
Original language description
Certain substances from the polycyclic aromatic hydrocarbons (PAHs) group are major inducers of respiratory tract carcinogenesis. The presented are the results of a serological epidemiological study aimed at monitoring the levels of anti-PAH antibodies and antibodies to PAH-DNA adducts in serum. The patients studied belonged both to the group of those with known lung disease (COPD and lung cancer), as well as to the healthy population of people who due to the work conditions or those at the place of residence can expect increased exposure to PAHs. In addition to the results proper that confirm increase of the genotoxic exposure risk to PAH in smoke-polluted places of residence and other PAH polluted environments. There has also been proved the relevance of still commonly used markers (DNA adducts), as well as the suitability of new markers, more favourable from the economic and practical viewpoints (anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA [anti-BPDE-DNA], anti-Benzo(a)pyre
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FC - Pneumology
OECD FORD branch
—

Project
<a href="/en/project/2B06150" target="_blank" >2B06150: Modulation of anti-polycyclic aromatic hydrocarbon antibody level in relation to smoking and lung diseases (cancer/non-cancer); and the increase of polycyclic aromatic hydrocarbon resistance of organism by immunization.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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