Influence of immunization with non-genotoxic PAH-KLH conjugates on the resistance of organisms exposed to benzo(a)pyrene.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F16556267%3A_____%2F12%3A%230000134" target="_blank" >RIV/16556267:_____/12:#0000134 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/12:00372907 RIV/00216208:11130/12:8916 RIV/00216208:11120/12:43901029 RIV/00064211:_____/12:#0000175
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Influence%20of%20immunization%20with%20non-genotoxic%20PAH-KLH%20conjugates%20on%20the%20resistance%20of%20organisms%20exposed%20to%20benzo(a)pyrene" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed?term=Influence%20of%20immunization%20with%20non-genotoxic%20PAH-KLH%20conjugates%20on%20the%20resistance%20of%20organisms%20exposed%20to%20benzo(a)pyrene</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Influence of immunization with non-genotoxic PAH-KLH conjugates on the resistance of organisms exposed to benzo(a)pyrene.
Original language description
Polycyclic aromatic hydrocarbons (PAH) are recognized as common environmental pollutants released into the environment from many natural as well as man-made sources, and some have been classified as potent carcinogens. The main representative of the carcinogenic PAH is benzo(a)pyrene (B(a)P) which is known to induce genotoxic effects in vitro and in vivo, detected as PAH-DNA adducts. Long-term PAH exposure may be accompanied by an immunological response with the formation of antibodies against PAH as well as against PAH-DNA adducts. This paper describes the use of four PAH-keyhole-limpet haemocyanin (KLH) conjugates for the induction of specific and cross-reactive anti-PAH antibodies and focuses on the potential protective effects of anti-PAH antibodies produced after immunization of mice. In the in vitro experiments with HepG-2 cells, the genotoxicity of the PAH-KLH conjugates and the neutralizing effect of induced anti-PAH antibodies were evaluated. The titer of specific anti-PAH ant
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/2B06150" target="_blank" >2B06150: Modulation of anti-polycyclic aromatic hydrocarbon antibody level in relation to smoking and lung diseases (cancer/non-cancer); and the increase of polycyclic aromatic hydrocarbon resistance of organism by immunization.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
ISSN
1383-5718
e-ISSN
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Volume of the periodical
Volume 742
Issue of the periodical within the volume
18
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
2-10
UT code for WoS article
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EID of the result in the Scopus database
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