Prevention and treatment of type 1 diabetes mellitus by the manipulation of invariant natural killer T cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907201" target="_blank" >RIV/00216208:11120/13:43907201 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10238-012-0199-0" target="_blank" >http://dx.doi.org/10.1007/s10238-012-0199-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10238-012-0199-0" target="_blank" >10.1007/s10238-012-0199-0</a>

Result language
angličtina
Original language name
Prevention and treatment of type 1 diabetes mellitus by the manipulation of invariant natural killer T cells
Original language description
Invariant natural killer T (iNKT) cells are CD1d-restricted T cells with regulatory functions. iNKT cells are numerically and functionally deficient in experimental models of type 1 diabetes mellitus (T1DM). Moreover, various experimental strategies correcting the defect of or stimulating iNKT cells prevent T1DM. Here, we review the data on the role of iNKT cells in the development of T1DM and discuss indications, obstacles and prospects of the use of iNKT cell manipulations in the prevention and treatment of human T1DM.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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