Potential role of invariant natural killer T cells in outcomes of acute myocardial infarction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909616" target="_blank" >RIV/00216208:11120/15:43909616 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/15:#0000476

Result on the web

<a href="http://dx.doi.org/10.1016/j.ijcard.2015.03.398" target="_blank" >http://dx.doi.org/10.1016/j.ijcard.2015.03.398</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2015.03.398" target="_blank" >10.1016/j.ijcard.2015.03.398</a>

Result language

angličtina

Original language name

Potential role of invariant natural killer T cells in outcomes of acute myocardial infarction

Original language description

Atherosclerosis (AS) is a chronic inflammatory lipid-storage disease of the large arteries. In addition to the key role of cholesterol homeostasis, both innate and adaptive immunity contribute to the evolution of the disease and its complications. Lipidantigens are recognized by Invariant Natural Killer T (iNKT) cells. iNKT cells are called unconventional T cells as they express markers of both T and NK cell lineages and exert rapidly effector functions. iNKT cells produce both pro-inflammatory and regulatory cytokines, harbor cytolytic potential and actively interact with other cells of the immune system. Due to their vast functional potential, iNKT cells are involved in the pathogenesis of various pathologic conditions including cancer, infection and autoimmune diseases. In conclusion, we suggest that iNKT cells play a pathogenic role in human atherosclerosis due to the promotion of inflammation. This is reflected and might even be mediated by fine tuning of NK receptors

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

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Volume of the periodical

187

Issue of the periodical within the volume

May

Country of publishing house

IE - IRELAND

Number of pages

3

Pages from-to

663-665

UT code for WoS article

000354905600175

EID of the result in the Scopus database

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