Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907591" target="_blank" >RIV/00216208:11120/13:43907591 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/13:00423300 RIV/00064173:_____/13:#0000373 RIV/00216305:26620/13:PU109318

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts

Original language description

Acellular materials of xenogenic origin are used worldwide as xenografts, and phase I trials of viable pig pancreatic islets are currently being performed. However, limited information is available on transmission of porcine endogenous retrovirus (PERV)after xenotransplantation and on the long-term immune response of recipients to xenoantigens. We analyzed the blood of burn patients who had received living pig-skin dressings for up to 8 wk for the presence of PERV as well as for the level and nature oftheir long term (maximum, 34 y) immune response against pig Ags. Although no evidence of PERV genomic material or anti-PERV Ab response was found, we observed a moderate increase in anti-alpha Gal Abs and a high and sustained anti-non-alpha Gal IgG response in those patients. Abs against the nonhuman sialic acid Neu5Gc constituted the anti-non-alpha Gal response with the recognition pattern on a sialoglycan array differing from that of burn patients treated without pig skin. These data

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

Continuities

R - Projekt Ramcoveho programu EK

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Immunology

ISSN

0022-1767

e-ISSN

—

Volume of the periodical

191

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

2907-2915

UT code for WoS article

000324206900008

EID of the result in the Scopus database

—