Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907679" target="_blank" >RIV/00216208:11120/13:43907679 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/13:10191786 RIV/00179906:_____/13:10191786 RIV/00064173:_____/13:#0000342
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejca.2013.06.033" target="_blank" >http://dx.doi.org/10.1016/j.ejca.2013.06.033</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejca.2013.06.033" target="_blank" >10.1016/j.ejca.2013.06.033</a>
Alternative languages
Result language
angličtina
Original language name
Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva
Original language description
Background: Human papillomavirus (HPV) contribution in vulvar intraepithelial lesions (VIN) and invasive vulvar cancer (IVC) is not clearly established. This study provides novel data on HPV markers in a large series of VIN and IVC lesions. Methods: Histologically confirmed VIN and IVC from 39 countries were assembled at the Catalan Institute of Oncology (ICO). HPV-DNA detection was done by polymerase chain reaction using SPF-10 broad-spectrum primers and genotyping by reverse hybridisation line probe assay (LiPA25) (version 1). IVC cases were tested for p16(INK4a) by immunohistochemistry (CINtec histology kit, ROCHE). An IVC was considered HPV driven if both HPV-DNA and p16(INK4a) overexpression were observed simultaneously. Data analyses included algorithms allocating multiple infections to calculate type-specific contribution and logistic regression models to estimate adjusted prevalence (AP) and its 95% confidence intervals (CI). Results: Of 2296 cases, 587 were VIN and 1709 IVC. H
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Cancer
ISSN
0959-8049
e-ISSN
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Volume of the periodical
49
Issue of the periodical within the volume
16
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
3450-3461
UT code for WoS article
000325425800008
EID of the result in the Scopus database
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