Expression of selected proteins in breast cancer brain metastases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907837" target="_blank" >RIV/00216208:11120/13:43907837 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5603/FHC.2013.0030" target="_blank" >http://dx.doi.org/10.5603/FHC.2013.0030</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5603/FHC.2013.0030" target="_blank" >10.5603/FHC.2013.0030</a>
Alternative languages
Result language
angličtina
Original language name
Expression of selected proteins in breast cancer brain metastases
Original language description
The aim of the study was to assess the immunohistochemical (IHC) profiles of SRC3, Pax2, ER, PgR, Her2, EGFR, CK5/6, and Ki67 proteins in breast-cancer brain metastasis. The study utilized tumor samples from 30 metastatic patients and calculated correlations between all IHC variables. In fourteen cases, primary breast cancers paired with secondary deposits were analyzed. We evaluated the association between IHC status in the primary and secondary deposits, grade, and histotype of the tumors. The examination of the metastatic deposits in all 30 patients resulted in positive detection in the following cases: SRC3 in 20 cases (66.6%), Pax2 in 22 (73.3%), ER in 22 (73.3%), PgR in 25 (83.3%), Her2 in 10 (33.3%), EGFR in 12 (40%), CK5/6 in 7 (23.3%), and Ki67 in 23 (76.6%). Grade 2 was found in 13.3% of all patients, and grade 3 in 86.7%. SRC3 and Pax2 were positive in both G2 and G3. Invasive lobular carcinoma and invasive ductal carcinoma were diagnosed in 23.3% and 76.7% of cases, respect
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia Histochemica et Cytobiologica
ISSN
0239-8508
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
3
Country of publishing house
PL - POLAND
Number of pages
6
Pages from-to
213-218
UT code for WoS article
000327203300005
EID of the result in the Scopus database
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