Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908599" target="_blank" >RIV/00216208:11120/14:43908599 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/14:10272135 RIV/75010330:_____/14:00010635 RIV/00216208:11140/14:10272135
Result on the web
<a href="http://dx.doi.org/10.1007/s10096-014-2081-3" target="_blank" >http://dx.doi.org/10.1007/s10096-014-2081-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10096-014-2081-3" target="_blank" >10.1007/s10096-014-2081-3</a>
Alternative languages
Result language
angličtina
Original language name
Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome
Original language description
Commensal bacteria in the colon may play a role in colorectal cancer (CRC) development. Recent studies from North America showed that Fusobacterium nucleatum (Fn) infection is over-represented in disease tissue versus matched normal tissue in CRC patients. Using quantitative real-time polymerase chain reaction (qPCR) of DNA extracted from colorectal tissue biopsies and surgical resections of three European cohorts totalling 122 CRC patients, we found an over-abundance of Fn in cancerous compared to matched normal tissue (p < 0.0001). To determine whether Fn infection is an early event in CRC development, we assayed Fn in colorectal adenoma (CRA) tissue from 52 Irish patients. While for all CRAs the Fn level was not statistically significantly higher indisease versus normal tissue (p = 0.06), it was significantly higher for high-grade dysplasia (p = 0.015). As a secondary objective, we determined that CRC patients with low Fn levels had a significantly longer overall survival time than
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Clinical Microbiology and Infectious Diseases
ISSN
0934-9723
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1381-1390
UT code for WoS article
000338723600013
EID of the result in the Scopus database
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