Effect of short-term hyperglycemia on adipose tissue fluxes of selected cytokines in vivo during multiple phases of diet-induced weight loss in obese women

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909502" target="_blank" >RIV/00216208:11120/15:43909502 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/15:#0000516
Result on the web
<a href="http://dx.doi.org/10.1210/jc.2014-3846" target="_blank" >http://dx.doi.org/10.1210/jc.2014-3846</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.2014-3846" target="_blank" >10.1210/jc.2014-3846</a>

Result language
angličtina
Original language name
Effect of short-term hyperglycemia on adipose tissue fluxes of selected cytokines in vivo during multiple phases of diet-induced weight loss in obese women
Original language description
Context: Hyperglycemia is suggested to be one of the drivers of the pro-inflammatory state observed in obese and diabetic patients. Objective: To investigate 1) whether subcutaneous abdominal adipose tissue (scAT) could be one of the important sources ofpro-inflammatory cytokines released in response to short-term hyperglycemia and 2) whether this secretion capacity could be influenced by weight loss. Design, Patients, and Interventions: Output of cytokines and proteins of acute phase from scAT in response to a 3 hours' hyperglycemic clamp was evaluated in 9 obese women in vivo using Fick's Principle. Moreover, the output of cytokines was analyzed during a multi-phase dietary intervention consisting of 1 month very-low calorie diet and subsequent 5 months weight stabilization phase. Main Outcome Measure(s): The levels of cytokines and proteins of acute phase (IL-6, IL-8, IL-1Ra, TNF-?, monocyte chemoattractant protein-1 (MCP-1), serum amyloid A and C-reactive protein) in arterial and
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NT14486" target="_blank" >NT14486: Role of fatty acids in regulation of immune state of adipose tissue</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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