The effect of prenatal methamphetamine exposure on recognition memory in adult rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909641" target="_blank" >RIV/00216208:11120/15:43909641 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/15:43914731
Result on the web
<a href="http://dx.doi.org/10.14712/23362936.2015.43" target="_blank" >http://dx.doi.org/10.14712/23362936.2015.43</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/23362936.2015.43" target="_blank" >10.14712/23362936.2015.43</a>
Alternative languages
Result language
angličtina
Original language name
The effect of prenatal methamphetamine exposure on recognition memory in adult rats
Original language description
The use of methamphetamine (MA) among pregnant women is an increasing world-wide health problem. Prenatal MA exposure may cause changes in foetus but the exact effects have remained unclear. The aim of this study is to present the effect of prenatal MA exposure on recognition memory in adult rats. Adult female Wistar rats were injected daily with D-methamphetamine HCl (MA; 5 mg/kg, s.c.) during the entire gestation period. Control females were treated with saline in the same regime. Adult male offspringwas administrated acutely by MA (1 mg/kg i.p.) or saline 30 minutes before beginning of an experiment. For testing recognition memory two tasks were chosen: Novel Object Recognition Test (NORT) and Object Location Test (OLT). Our results demonstrate that prenatally MA-exposed animals were worse in NORT independently on an acute administration of MA in adulthood. Prenatally MA-exposed rats did not deteriorate in OLT, but after acute administration of MA in adulthood, there was significan
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F10%2F0580" target="_blank" >GAP303/10/0580: What is the role of mesolimbic reward circuit in the long-term effect of prenatal methamphetamine exposure in rats?</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Prague Medical Report
ISSN
1214-6994
e-ISSN
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Volume of the periodical
116
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
9
Pages from-to
31-39
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-84936110075