The effect of environmental chemicals on the tumor microenvironment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909880" target="_blank" >RIV/00216208:11120/15:43909880 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/carcin/bgv035" target="_blank" >http://dx.doi.org/10.1093/carcin/bgv035</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/carcin/bgv035" target="_blank" >10.1093/carcin/bgv035</a>

Result language

angličtina

Original language name

The effect of environmental chemicals on the tumor microenvironment

Original language description

Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects on the tumor microenvironment. In turn, the tumor microenvironment consists of a complex interaction among blood vessels that feed the tumor, the extracellular matrix that provides structural and biochemical support, signaling molecules that send messages and soluble factors such as cytokines. The tumor microenvironment also consists of many host cellular effectors including multipotent stromal cells/mesenchymal stem cells, fibroblasts, endothelial cell precursors, antigen-presenting cells, lymphocytes and innate immune cells. Carcinogens can influence the tumor microenvironment through eff

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carcinogenesis

ISSN

0143-3334

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

24

Pages from-to

"S160"-"S183"

UT code for WoS article

000357048100009

EID of the result in the Scopus database

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