Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909887" target="_blank" >RIV/00216208:11120/15:43909887 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/15:00446320 RIV/00216208:11310/15:10321607
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbr.2015.07.001" target="_blank" >http://dx.doi.org/10.1016/j.bbr.2015.07.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbr.2015.07.001" target="_blank" >10.1016/j.bbr.2015.07.001</a>

Result language
angličtina
Original language name
Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?
Original language description
The aim of the present study was an evaluation of prenatal exposure to acute methamphetamine (MA) treatment on manifestations of anxiety. Anxiety was evaluated in adult animals in three different experimental models: the Elevated plus-maze (EPM), Socialinteraction test (SIT) and Ultrasound vocalization (USV). Female rats were administered saline (S) or MA (5mg/kg) daily throughout their entire gestation period. The male progeny, in adulthood, were administered with challenge dose of S or MA (1mg/kg) prior to evaluation of anxiety. The study demonstrated that prenatal MA exposure increased the anxiogenic effect on evaluated behaviour patterns in the USV model and to a lesser degree in the EPM model. In addition, the acute MA challenge in adulthood decreased the time spent during social interaction suggesting an anxiogenic effect in the SIT model as well. On the other hand, some of the evaluated parameters (e.g., the number of head-dipping in the EPM and number of dropped boluses in the
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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