Effect of prolonged exposure to sublethal concentrations of DDT and DDE on protein expression in human pancreatic beta cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909891" target="_blank" >RIV/00216208:11120/15:43909891 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/15:00452051
Result on the web
<a href="http://dx.doi.org/10.1016/j.envres.2015.06.046" target="_blank" >http://dx.doi.org/10.1016/j.envres.2015.06.046</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.envres.2015.06.046" target="_blank" >10.1016/j.envres.2015.06.046</a>
Alternative languages
Result language
angličtina
Original language name
Effect of prolonged exposure to sublethal concentrations of DDT and DDE on protein expression in human pancreatic beta cells
Original language description
Pollution of the environment represents one of less explored potential reasons for the worldwide epidemic of type 2 diabetes. One of the most prevalent organochlorine pollutants remains the pesticide DDT and its degradation product DDE. Despite some epidemiologic correlations between levels of DDT and DDE in human organism and the prevalence of diabetes, there is almost no information about the exact targets of these compounds inside pancreatic beta cells. To detect functional areas of pancreatic beta cells that could be affected by exposure to DDT and DDE, we analyzed changes in protein expression in the NES2Y human pancreatic beta cell line exposed to three sublethal concentrations (0.1?M, 1?M, 10?M) of DDT and DDE for 1 month. Protein separation andidentification was achieved using high-resolution 2D-electrophoresis, computer analysis and mass spectrometry. With these techniques, four proteins were found downregulated after exposure to 10?M DDT: three cytoskeletal proteins (cytoker
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Research
ISSN
0013-9351
e-ISSN
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Volume of the periodical
142
Issue of the periodical within the volume
October
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
257-263
UT code for WoS article
000363602800031
EID of the result in the Scopus database
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