Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43910373" target="_blank" >RIV/00216208:11120/15:43910373 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/15:#0000487

Result on the web

<a href="http://dx.doi.org/10.1186/s13054-015-1112-5" target="_blank" >http://dx.doi.org/10.1186/s13054-015-1112-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13054-015-1112-5" target="_blank" >10.1186/s13054-015-1112-5</a>

Result language

angličtina

Original language name

Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports

Original language description

INTRODUCTION: Propofol infusion syndrome (PRIS) is a rare, but potentially lethal adverse effect of a commonly used drug. We aimed to review and correlate experimental and clinical data about this syndrome. METHODS: We searched for all case reports published between 1990 and 2014 and for all experimental studies on PRIS pathophysiology. We analysed the relationship between signs of PRIS and the rate and duration of propofol infusion causing PRIS. By multivariate logistic regression we looked at the riskfactors for mortality. RESULTS: Knowledge about PRIS keeps evolving. Compared to earlier case reports in the literature, recently published cases describe older patients developing PRIS at lower doses of propofol, in whom arrhythmia, hypertriglyceridaemia and fever are less frequently seen, with survival more likely. We found that propofol infusion rate and duration, the presence of traumatic brain injury and fever are factors independently associated with mortality in reported cases of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Critical Care

ISSN

1466-609X

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

Article ID 398

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000364556700001

EID of the result in the Scopus database

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