Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43910511" target="_blank" >RIV/00216208:11120/15:43910511 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/15:#0000495

Result on the web

<a href="http://dx.doi.org/10.1186/s13054-015-1160-x" target="_blank" >http://dx.doi.org/10.1186/s13054-015-1160-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13054-015-1160-x" target="_blank" >10.1186/s13054-015-1160-x</a>

Result language

angličtina

Original language name

Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness

Original language description

BACKGROUND: Mitochondrial damage occurs in the acute phase of critical illness, followed by activation of mitochondrial biogenesis in survivors. It has been hypothesized that bioenergetics failure of skeletal muscle may contribute to the development of ICU-acquired weakness. The aim of the present study was to determine whether mitochondrial dysfunction persists until protracted phase of critical illness. METHODS: In this single-centre controlled-cohort ex vivo proof-of-concept pilot study, we obtainedvastus lateralis biopsies from ventilated patients with ICU-acquired weakness (n = 8) and from age and sex-matched metabolically healthy controls (n = 8). Mitochondrial functional indices were measured in cytosolic context by high-resolution respirometryin tissue homogenates, activities of respiratory complexes by spectrophotometry and individual functional capacities were correlated with concentrations of electron transport chain key subunits from respiratory complexes II, III, IV and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FI - Traumatology and orthopaedics

OECD FORD branch

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Project

<a href="/en/project/NT12319" target="_blank" >NT12319: Multiparameter metabolic analysis of human myoblasts related to the pathogenesis of intensive care unit acquired weakness</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Critical Care

ISSN

1466-609X

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

"ID 448"

UT code for WoS article

000367057400001

EID of the result in the Scopus database

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