Chronic dietary exposure to branched chain amino acids impairs glucose disposal in vegans but not in omnivores
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43912925" target="_blank" >RIV/00216208:11120/17:43912925 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/17:N0000106
Result on the web
<a href="http://dx.doi.org/10.1038/ejcn.2016.274" target="_blank" >http://dx.doi.org/10.1038/ejcn.2016.274</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ejcn.2016.274" target="_blank" >10.1038/ejcn.2016.274</a>
Alternative languages
Result language
angličtina
Original language name
Chronic dietary exposure to branched chain amino acids impairs glucose disposal in vegans but not in omnivores
Original language description
BACKGROUND/OBJECTIVES: Branched chain amino acids (BCAA) are among nutrients strongly linked with insulin sensitivity (IS) measures. We investigated the effects of a chronic increase of BCAA intake on IS in two groups of healthy subjects differing in their basal consumption of BCAA, that is, vegans and omnivores. SUBJECTS/METHODS: Eight vegans and eight matched omnivores (five men and three women in each group) received 15 g (women) or 20 g (men) of BCAA daily for 3 months. Anthropometry, blood analyses, glucose clamp, arginine test, subcutaneous abdominal adipose tissue (AT) and skeletal muscle (SM) biopsies (mRNA levels of selected metabolic markers, respiratory chain (RC) activity) were performed at baseline, after the intervention and after a 6 month wash-out period. RESULTS: Compared with omnivores, vegans had higher IS at baseline (GIR, glucose infusion rate: 9.6+-2.4 vs 7.1+-2.4 mg/kg/min, 95% CI for difference: 0.55 to 5.82) that declined after the intervention and returned to baseline values after the wash-out period (changes in GIR with 95% CI, 3-0 months: -1.64 [-2.5; -0.75] and 9-3 months: 1.65 [0.75; 2.54] mg/kg/min). No such change was observed in omnivores. In omnivores the intervention led to an increased expression of lipogenic genes (DGAT2, FASN, PPARγ, SCD1) in AT. SM RC activity increased in both groups. CONCLUSIONS: Negative impact of increased BCAA intake on IS was only detected in vegans, that is, subjects with low basal amino acids/BCAA intake, which appear to be unable to induce sufficient compensatory changes within AT and SM on a BCAA challenge.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30308 - Nutrition, Dietetics
Result continuities
Project
<a href="/en/project/NT14416" target="_blank" >NT14416: Effect of branched-chain amino acids and saturated fatty acids on development of insulin resistance</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Clinical Nutrition
ISSN
0954-3007
e-ISSN
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Volume of the periodical
71
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
594-601
UT code for WoS article
000400599400006
EID of the result in the Scopus database
2-s2.0-85011308934