Lipoblasts in spindle cell and pleomorphic lipomas: a close scrutiny
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43916058" target="_blank" >RIV/00216208:11120/17:43916058 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/17:10367203
Result on the web
<a href="http://dx.doi.org/10.1016/j.humpath.2017.05.006" target="_blank" >http://dx.doi.org/10.1016/j.humpath.2017.05.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.humpath.2017.05.006" target="_blank" >10.1016/j.humpath.2017.05.006</a>
Alternative languages
Result language
angličtina
Original language name
Lipoblasts in spindle cell and pleomorphic lipomas: a close scrutiny
Original language description
The presence and frequency of lipoblasts (LPB) in spindle cell lipomas (SCL) and pleomorphic lipomas (PL) has never been studied in detail on a histologically, immunohistochemically and molecular genetically validated set of tumors. The authors investigated this feature by reviewing 91 cases of SCL and 38 PL. When more than 3 unequivocal LPB were found, the case was regarded as positive for the presence of LPB. All positive cases were then stained with CD34 and retinoblastoma (Rb) protein antibodies and tested by fluorescence in situ hybridization for MDM2 and CDK4 amplifications and the FUS gene rearrangements. The patients with SCL and PL containing LPB were 14 women and 47 men, the rest were of unknown gender. The cases usually presented as superficial, well-circumscribed soft tissue masses and most commonly occurred in the upper back and neck. CD34 was expressed in all cases, while Rb protein was consistently absent in all. Molecular genetic results, when available, were in concordance with the morphological diagnosis of SCL/PL. LPB were found in 37 (41%) cases of SCL and 25 cases of PL (66%). While in many cases they are inconspicuous, in some others they constitute a very prominent component of the tumor. It is important to be aware of this fact in order to avoid misinterpretation as liposarcoma.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Human Pathology
ISSN
0046-8177
e-ISSN
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Volume of the periodical
65
Issue of the periodical within the volume
July
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
140-146
UT code for WoS article
000408297200017
EID of the result in the Scopus database
2-s2.0-85019098344