Atypical mitoses in pleomorphic lipomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10368894" target="_blank" >RIV/00216208:11140/17:10368894 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.humpath.2017.06.024" target="_blank" >http://dx.doi.org/10.1016/j.humpath.2017.06.024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.humpath.2017.06.024" target="_blank" >10.1016/j.humpath.2017.06.024</a>
Alternative languages
Result language
angličtina
Original language name
Atypical mitoses in pleomorphic lipomas
Original language description
In our recent article published in this journal, we evaluated the presence and frequency of lipoblats in spindle cell and pleomorfphic lipomas (SCL/PL). Overall, lipoblasts were found in 66% of PL. These cases, which mostly occurred in the typical clinical setting of PL, were also molecular genetically tested to exclude MDM2 and CDK4 amplifications, and stained for CD34 and retinoblastoma protein to further validate the diagnosis(1). Recently, we have been contacted by Dr kosemehmetoglu who presented to us cases of PL that displayed unquestionable atypical mitoses and thus led to erroneous diagnosis of liposarcoma. After a review of the literature, we have found only 3 monographs briefly mentioning this histologic feature of PL, which may be very confusing and misleading (2-4). The frequency of atypical mitoses in PL is virtually unknown, Because it might represent an important diagnostic pitfall, we again reviewed our histologically, immmunohistochemically, and molecular genetically validated cohort of 25 PL to assess the frequency of atypical mitoses, which are, however, a more widely acknowl-edged feature of PL. Thus, besides the routine presence of lipoblasts, we would also additionally like to highlight the possibility of encountering atypical mitosis in PL, which may lead to erroneous overdiagnosis of these lesions, especially as atypical lipomatous tumor/well-differentiated liposarcoma.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Human Pathology
ISSN
0046-8177
e-ISSN
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Volume of the periodical
70
Issue of the periodical within the volume
December
Country of publishing house
US - UNITED STATES
Number of pages
1
Pages from-to
143
UT code for WoS article
000422700900022
EID of the result in the Scopus database
2-s2.0-85035218160