Synthetic osmotic dilators for cervical preparation prior to abortion: An international multicentre observational study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43917168" target="_blank" >RIV/00216208:11120/18:43917168 - isvavai.cz</a>

Alternative codes found

RIV/00023698:_____/18:N0000009

Result on the web

<a href="https://doi.org/10.1016/j.ejogrb.2018.07.013" target="_blank" >https://doi.org/10.1016/j.ejogrb.2018.07.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejogrb.2018.07.013" target="_blank" >10.1016/j.ejogrb.2018.07.013</a>

Result language

angličtina

Original language name

Synthetic osmotic dilators for cervical preparation prior to abortion: An international multicentre observational study

Original language description

Objectives: To evaluate the outcomes with the use of Dilapan-S for cervical preparation prior to medical or surgical abortion. Study design: International, multicentre, prospective observational study in women between 6 + 0-24 + 0 weeks&apos; gestation. The study was conducted across 7 study sites in 4 countries, between 1/5/2015 to 31/12/2016. The primary outcomes studied were the number of dilators used and the duration required for cervical preparation prior to abortion. Secondary outcomes were complications of dilator use and infection. Participants were followed-up for 4 weeks post procedure to capture any delayed complications. Results: A total of 483 women were enrolled with 439 women eligible for analysis. Medical abortion was performed in 38% (n = 165) women and surgical abortion in 62% (n = 274). For medical abortions and surgical abortions, an average of 3 osmotic dilators for time interval of 4-7 hours provided effective cervical preparation. Medical abortions were performed as day-case procedures (&lt;12 h) in 81% of women. There was no difference in using either adjunctive misoprostol or Dilapan-S followed by misoprostol for cervical ripening effect to achieve complete medical abortion. Dilapan-S permitted surgical abortions to be performed as same-day procedures (&lt;12 h), in 85% of women regardless of gestational age and without the need to use adjunctive or additional misoprostol. There were no serious adverse events reported with the use of Dilapan-S, including in women with a previous caesarean section. The overall infectious morbidity was 0.9% of cases with no causal relationship with the use of synthetic osmotic dilator use (fora length &lt;24 h). In addition, Dilapan-S was reported as easy to insert and remove in over 90% of women. Conclusion: Dilapan-S is a safe and effective method for cervical preparation for medical and surgical abortions up to 24 weeks&apos; gestation. It allows medical and surgical abortions to be performed as day case procedures and is associated with a low complication rate. Future research should aim at directly comparing Dilapan-S and preferred pharmacological agents in a randomised controlled trial.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Obstetrics &amp; Gynecology and Reproductive Biology

ISSN

0301-2115

e-ISSN

—

Volume of the periodical

228

Issue of the periodical within the volume

September

Country of publishing house

IE - IRELAND

Number of pages

6

Pages from-to

249-254

UT code for WoS article

000445991800042

EID of the result in the Scopus database

2-s2.0-85050155943