Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43917447" target="_blank" >RIV/00216208:11120/18:43917447 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/18:10384928 RIV/00216208:11150/18:10384928 RIV/00179906:_____/18:10384928 RIV/00064173:_____/18:N0000092 RIV/00064203:_____/18:10384928

Result on the web

<a href="https://doi.org/10.1186/s40425-018-0446-3" target="_blank" >https://doi.org/10.1186/s40425-018-0446-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40425-018-0446-3" target="_blank" >10.1186/s40425-018-0446-3</a>

Result language

angličtina

Original language name

Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients

Original language description

A high density of tumor-infiltrating CD8+ T cells and CD20+ B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP+ DCs is robustly associated with an immune contexture characterized by TH1 polarization and cytotoxic activity. We showed that both mature DCs and CD20+ B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP+ DCs and CD20+ B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP+ DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal for ImmunoTherapy of Cancer

ISSN

2051-1426

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

December

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

"Article 139"

UT code for WoS article

000452804900001

EID of the result in the Scopus database

2-s2.0-85058319459