Comment on Mulukutla et al. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes. Diabetes Care 2018;41:2637-2640
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F19%3A43918116" target="_blank" >RIV/00216208:11120/19:43918116 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.2337/dc19-0022" target="_blank" >https://doi.org/10.2337/dc19-0022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2337/dc19-0022" target="_blank" >10.2337/dc19-0022</a>
Alternative languages
Result language
angličtina
Original language name
Comment on Mulukutla et al. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes. Diabetes Care 2018;41:2637-2640
Original language description
I read with great interest the article by Mulukutla et al. (1) demonstrating that antibodies against the luminal (extracellular) domain of phosphatase IA-2, termed IA-2EC (amino acids 26-577), are expressed by patients with ketosis-prone diabetes. Among patients that were negative for other αIA-2 autoantibodies, the αIA-2EC antibodies were reported in 2% of patients with ketosis-prone diabetes without the presence of autoantibodies (1), 6% (2) or 7% (3) of patients with type 1 diabetes, and 5% of patients diagnosed with type 2 diabetes (3). Despite the fact that the mRNA signal of IA-2 is ubiquitous and protein expression is high in various neuroendocrine cells, the data on αIA-2EC autoantibodies from other neuroendocrine disorders are lacking.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetes Care
ISSN
0149-5992
e-ISSN
—
Volume of the periodical
42
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
1
Pages from-to
"e81"
UT code for WoS article
000465238900007
EID of the result in the Scopus database
2-s2.0-85065114320