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Postpartum epigenetic profile of cardiovascular microRNAs in women exposed to pregnancy-related complications

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43919380" target="_blank" >RIV/00216208:11120/20:43919380 - isvavai.cz</a>

  • Result on the web

    <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020088704&tab=PCTBIBLIO&_cid=P10-KA2B6F-45104-1" target="_blank" >https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020088704&tab=PCTBIBLIO&_cid=P10-KA2B6F-45104-1</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Postpartum epigenetic profile of cardiovascular microRNAs in women exposed to pregnancy-related complications

  • Original language description

    The present invention provides a method of predicting a risk of onset and development of cardiovascular and/or cerebrovascular disease for a woman with a history of pregnancy-related complications selected from gestational hypertension, preeclampsia and/or fetal growth restriction, said method comprising the steps of: - determining the level of expression of at least one microRNA marker selected from the group consisting of miR-1-3p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-29a-3p, miR-100-5p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-199a-5p, miR-221-3p, and miR-499a-5p and combinations thereof, in a whole peripheral venous blood sample taken from the woman postpartum at least 3 years after delivery, preferably 3-11 years after delivery; - comparing the determined level(s) of expression of the said at least one microRNA marker with a reference cut-off value, wherein said reference cut-off value is obtained by statistical analysis of samples from women with a history of pregnancy-related complications and samples from women without a history of pregnancy-related complications; - wherein the upregulation of the said at least one microRNA marker exceeding the reference cut-off value indicates the risk of onset and development of cardiovascular and/or cerebrovascular disease for the woman.

  • Czech name

  • Czech description

Classification

  • Type

    P - Patent

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/NV16-27761A" target="_blank" >NV16-27761A: Long-term monitoring of complex cardiovascular profile in the mother, fetus and offspring descending from pregnancy related complications</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Patent/design ID

    WO/2020/088704

  • Publisher

    EPO_1 -

  • Publisher name

    European Patent Office

  • Place of publication

    Munich, The Hague, Berlin, Vienna, Brussels

  • Publication country

  • Date of acceptance

    May 7, 2020

  • Owner name

    Univerzita Karlova, 3. lékařská fakulta

  • Method of use

    A - Výsledek využívá pouze poskytovatel

  • Usage type

    A - K využití výsledku jiným subjektem je vždy nutné nabytí licence