A method of predicting a risk of cardiovascular disease for a child born from a complicated pregnancy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43919394" target="_blank" >RIV/00216208:11120/20:43919394 - isvavai.cz</a>
Alternative codes found
RIV/00023698:_____/20:N0000007
Result on the web
<a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020088703&_cid=P10-KA2BWZ-56206-1" target="_blank" >https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020088703&_cid=P10-KA2BWZ-56206-1</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A method of predicting a risk of cardiovascular disease for a child born from a complicated pregnancy
Original language description
The present invention provides a method of predicting a risk of onset and development of cardiovascular disease for a child born from a pregnancy complicated by gestational hypertension, preeclampsia and/or fetal growth restriction, or in a child born from a physiological pregnancy having an abnormal postnatal clinical finding, said method comprising the steps of: - determining the level of expression of at least one microRNA marker selected from the group consisting of miR-1-3p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-26a-5p, miR-29a-3p, miR-103a-3p, miR-125b-5p, miR-126-3p, miR-133a-3p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-210-3p, miR-342-3p and combinations thereof, in a sample of blood taken from the child; - comparing the determined level(s) of expression of the said at least one microRNA marker with reference cut-off value, wherein said reference cut-off value is obtained by statistical analysis of samples from children from physiological pregnancies and samples from children from complicated pregnancies; - wherein the aberrant regulation of the said at least one microRNA marker exceeding the reference cut-off value, or below the reference cut-off value, respectively, indicates the risk of onset and development of cardiovascular disease for the child.
Czech name
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Czech description
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Classification
Type
P - Patent
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV16-27761A" target="_blank" >NV16-27761A: Long-term monitoring of complex cardiovascular profile in the mother, fetus and offspring descending from pregnancy related complications</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
WO/2020/088703
Publisher
EPO_1 -
Publisher name
European Patent Office
Place of publication
Munich, The Hague, Berlin, Vienna, Brussels
Publication country
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Date of acceptance
May 7, 2020
Owner name
Univerzita Karlova, 3. lékařská fakulta
Method of use
A - Výsledek využívá pouze poskytovatel
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence