Mitochondria-targeted compounds in the treatment of cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43919920" target="_blank" >RIV/00216208:11120/20:43919920 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.4149/neo_2020_190725N671" target="_blank" >https://doi.org/10.4149/neo_2020_190725N671</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2020_190725N671" target="_blank" >10.4149/neo_2020_190725N671</a>

Result language

angličtina

Original language name

Mitochondria-targeted compounds in the treatment of cancer

Original language description

Mitochondria are highly dynamic organelles involved in many cellular functions. Beyond their central role in metabolism, they also take a part in maintaining calcium homeostasis, cell death, immunity and ROS production. Changes in these functions have been shown to be crucial for the adaptation and survival of cancer cells. Mitochondria therefore constitute a promising target for the development of novel anticancer agents. The triphenylphosphonium (TPP+) moiety has been widely used to target molecules into mitochondria. TPP+ derivatives of a variety of conventional cytostatic drugs, natural substances, metformin, antioxidants or a range of newly synthesized molecules have shown promising results against cancer cells. In this review we discuss biochemical differences between cancer cells and normal cells with specific focus on mitochondria, and how mitochondrially targeted molecules can be used to selectively affect mitochondrial function in normal and cancer cells. We summarize the published data on mitochondrially targeted anticancer agents and propose future research avenues.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

—

Volume of the periodical

67

Issue of the periodical within the volume

3

Country of publishing house

SK - SLOVAKIA

Number of pages

11

Pages from-to

450-460

UT code for WoS article

000542668500002

EID of the result in the Scopus database

2-s2.0-85084916388