Mitochondrial targeting of [alpha]-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00360075" target="_blank" >RIV/61388963:_____/11:00360075 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/11:00360075 RIV/68378050:_____/11:00360075 RIV/00027162:_____/11:#0000797
Result on the web
<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2011.02.032" target="_blank" >http://dx.doi.org/10.1016/j.freeradbiomed.2011.02.032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2011.02.032" target="_blank" >10.1016/j.freeradbiomed.2011.02.032</a>

Result language
angličtina
Original language name
Mitochondrial targeting of [alpha]-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy
Original language description
Mitochondria are emerging as intriguing targets for anti-cancer agents.We tested here a novel approach,whereby the mitochondrially targeted delivery of anti-cancer drugs is enhanced by the addition of a triphenylphosphonium group (TPP+). A mitochondrially targeted analog of vitamin E succinate (MitoVES),modified by tagging the parental compound with TPP+,induced considerably more robust apoptosis in cancer cells with a 1?2 log gain in anti-cancer activity compared to the unmodified counterpart, while maintaining selectivity for malignant cells.This is because MitoVES associates with mitochondria and causes fast generation of ROS that then trigger mitochondria-dependent apoptosis, involving transcriptional modulation of the Bcl-2 family proteins.MitoVESproved superior in suppression of experimental tumors compared to the untargeted analog. We propose that mitochondrially targeted delivery of anti-cancer agents offers a new paradigm for increasing the efficacy of anti-cancer compounds
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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