Mitochondrially Targeted Vitamin E Succinate Modulates Expression of Mitochondrial DNA Transcripts and Mitochondrial Biogenesis.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43899524" target="_blank" >RIV/60461373:22330/15:43899524 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/15:00444249

Result on the web

<a href="http://dx.doi.org/10.1089/ars.2013.5594" target="_blank" >http://dx.doi.org/10.1089/ars.2013.5594</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/ars.2013.5594" target="_blank" >10.1089/ars.2013.5594</a>

Result language

angličtina

Original language name

Mitochondrially Targeted Vitamin E Succinate Modulates Expression of Mitochondrial DNA Transcripts and Mitochondrial Biogenesis.

Original language description

Aims: To assess the effect of mitochondrially targeted vitamin E (VE) analogs on mitochondrial function and biogenesis. Results: Mitochondrially targeted vitamin E succinate (MitoVES) is an efficient inducer of apoptosis in cancer cells. Here, we show that unlike its untargeted counterpart alpha-tocopheryl succinate, MitoVES suppresses proliferation of cancer cells at sub-apoptotic doses by way of affecting the mitochondrial DNA (mtDNA) transcripts. We found that MitoVES strongly suppresses the level ofthe displacement loop transcript followed by those of mtDNA genes coding for subunits of mitochondrial complexes. This process is coupled to the inhibition of mitochondrial respiration, dissipation of the mitochondrial membrane potential, and generationof reactive oxygen species. In addition, exposure of cancer cells to MitoVES led to decreased expression of TFAM and diminished mitochondrial biogenesis. The inhibition of mitochondrial transcription was replicated in vivo in a mouse mod

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Antioxidants &amp; Redox Signaling

ISSN

1523-0864

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

18

Pages from-to

883-900

UT code for WoS article

000351944100001

EID of the result in the Scopus database

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